Ibudilast Attenuates Folic Acid–Induced Acute Kidney Injury by Blocking Pyroptosis Through TLR4-Mediated NF-κB and MAPK Signaling Pathways

Folic acid (FA)-induced renal tubule damage, which is characterized by extensive inflammation, is a common model of acute kidney injury (AKI). Pyroptosis, a pro-inflammatory form of cell death due to the activation of inflammatory caspases, is involved in AKI progression. Ibudilast, a TLR4 antagonis...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Xue, Zou, Yu, Fu, Yuan-Yuan, Xing, Jia, Wang, Kai-Yue, Wan, Peng-Zhi, Wang, Mo, Zhai, Xiao-Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139578/
https://www.ncbi.nlm.nih.gov/pubmed/34025417
http://dx.doi.org/10.3389/fphar.2021.650283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139578/
https://www.ncbi.nlm.nih.gov/pubmed/34025417
http://dx.doi.org/10.3389/fphar.2021.650283

Ejemplares similares