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Ibudilast Attenuates Folic Acid–Induced Acute Kidney Injury by Blocking Pyroptosis Through TLR4-Mediated NF-κB and MAPK Signaling Pathways

Folic acid (FA)-induced renal tubule damage, which is characterized by extensive inflammation, is a common model of acute kidney injury (AKI). Pyroptosis, a pro-inflammatory form of cell death due to the activation of inflammatory caspases, is involved in AKI progression. Ibudilast, a TLR4 antagonis...

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Detalles Bibliográficos
Autores principales:	Li, Xue, Zou, Yu, Fu, Yuan-Yuan, Xing, Jia, Wang, Kai-Yue, Wan, Peng-Zhi, Wang, Mo, Zhai, Xiao-Yue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139578/ https://www.ncbi.nlm.nih.gov/pubmed/34025417 http://dx.doi.org/10.3389/fphar.2021.650283

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