A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery

Cell division cycle 7 (CDC7), a serine/threonine kinase, plays important roles in DNA replication. We developed a highly specific CDC7 inhibitor, TAK-931, as a clinical cancer therapeutic agent. This study aimed to identify the potential combination partners of TAK-931 for guiding its clinical devel...

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Detalles Bibliográficos
Autores principales: Iwai, Kenichi, Nambu, Tadahiro, Kashima, Yukie, Yu, Jie, Eng, Kurt, Miyamoto, Kazumasa, Kakoi, Kazuyo, Gotou, Masamitsu, Takeuchi, Toshiyuki, Kogame, Akifumi, Sappal, Jessica, Murai, Saomi, Haeno, Hiroshi, Kageyama, Shun-Ichiro, Kurasawa, Osamu, Niu, Huifeng, Kannan, Karuppiah, Ohashi, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139593/
https://www.ncbi.nlm.nih.gov/pubmed/34020950
http://dx.doi.org/10.1126/sciadv.abf0197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139593/
https://www.ncbi.nlm.nih.gov/pubmed/34020950
http://dx.doi.org/10.1126/sciadv.abf0197

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