Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology

Aging leads to a progressive deterioration of meningeal lymphatics and peripheral immunity, which may accelerate cognitive decline. We hypothesized that an age-related reduction in C-C chemokine receptor type 7 (CCR7)–dependent egress of immune cells through the lymphatic vasculature mediates some a...

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Detalles Bibliográficos
Autores principales: Da Mesquita, Sandro, Herz, Jasmin, Wall, Morgan, Dykstra, Taitea, de Lima, Kalil Alves, Norris, Geoffrey T., Dabhi, Nisha, Kennedy, Tatiana, Baker, Wendy, Kipnis, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139596/
https://www.ncbi.nlm.nih.gov/pubmed/34020948
http://dx.doi.org/10.1126/sciadv.abe4601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139596/
https://www.ncbi.nlm.nih.gov/pubmed/34020948
http://dx.doi.org/10.1126/sciadv.abe4601

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