New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention, and Cure

Previously, we showed that substitution of HIV-1 envelope (Env) residue 375-Ser by bulky aromatic residues enhances binding to rhesus CD4 and enables primary HIV-1 Envs to support efficient replication as simian-human immunodeficiency virus (SHIV) chimeras in rhesus macaques (RMs). Here, we test thi...

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Detalles Bibliográficos
Autores principales: Li, Hui, Wang, Shuyi, Lee, Fang-Hua, Roark, Ryan S., Murphy, Alex I., Smith, Jessica, Zhao, Chengyan, Rando, Juliette, Chohan, Neha, Ding, Yu, Kim, Eunlim, Lindemuth, Emily, Bar, Katharine J., Pandrea, Ivona, Apetrei, Cristian, Keele, Brandon F., Lifson, Jeffrey D., Lewis, Mark G., Denny, Thomas N., Haynes, Barton F., Hahn, Beatrice H., Shaw, George M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Pathogenesis and Immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139694/
https://www.ncbi.nlm.nih.gov/pubmed/33658341
http://dx.doi.org/10.1128/JVI.00071-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139694/
https://www.ncbi.nlm.nih.gov/pubmed/33658341
http://dx.doi.org/10.1128/JVI.00071-21

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