Cargando…

The Furin-S2′ Site in Avian Coronavirus Plays a Key Role in Central Nervous System Damage Progression

The furin cleavage site plays an important role in virus pathogenicity. The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) harbors a furin cleavage site insertion, in contrast to SARS-CoV, which may be related to its stronger communicability. An avian coronavirus with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Jinlong, Zhao, Ye, Hu, Yanxin, Zhao, Jing, Xue, Jia, Zhang, Guozhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Pathogenesis and Immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139701/ https://www.ncbi.nlm.nih.gov/pubmed/33727330 http://dx.doi.org/10.1128/JVI.02447-20

Ejemplares similares

Single-Cell RNA Sequencing Reveals the Diversity of the Immunological Landscape following Central Nervous System Infection by a Murine Coronavirus
por: Syage, Amber R., et al.
Publicado: (2020)

A Temperature-Sensitive Recombinant of Avian Coronavirus Infectious Bronchitis Virus Provides Complete Protection against Homologous Challenge
por: Keep, Sarah, et al.
Publicado: (2022)

Viral Factors Important for Efficient Replication of Influenza A Viruses in Cells of the Central Nervous System
por: Siegers, Jurre Y., et al.
Publicado: (2019)

Characterization of Macrophage-Tropic HIV-1 Infection of Central Nervous System Cells and the Influence of Inflammation
por: Woodburn, Blaide M., et al.
Publicado: (2022)

Identification of Amino Acids within Nonstructural Proteins 10 and 14 of the Avian Coronavirus Infectious Bronchitis Virus That Result in Attenuation In Vivo and In Ovo
por: Keep, Sarah, et al.
Publicado: (2022)

Defensive Perimeter in the Central Nervous System: Predominance of Astrocytes and Astrogliosis during Recovery from Varicella-Zoster Virus Encephalitis
por: Carpenter, John E., et al.
Publicado: (2015)

Central Nervous System Inflammation and Infection during Early, Nonaccelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques
por: Hsu, Denise C., et al.
Publicado: (2018)

Microglia Do Not Restrict SARS-CoV-2 Replication following Infection of the Central Nervous System of K18-Human ACE2 Transgenic Mice
por: Olivarria, Gema M., et al.
Publicado: (2022)

The N-Terminal Region of Middle East Respiratory Syndrome Coronavirus Accessory Protein 8b Is Essential for Enhanced Virulence of an Attenuated Murine Coronavirus
por: Li, Yuming, et al.
Publicado: (2022)

Contribution of Segment 3 to the Acquisition of Virulence in Contemporary H9N2 Avian Influenza Viruses
por: Clements, Anabel L., et al.
Publicado: (2020)

Glycine at Position 622 in PB1 Contributes to the Virulence of H5N1 Avian Influenza Virus in Mice
por: Feng, Xiaoxiao, et al.
Publicado: (2016)

Long-Term Protective Effect of Serial Infections with H5N8 Highly Pathogenic Avian Influenza Virus in Wild Ducks
por: Caliendo, Valentina, et al.
Publicado: (2022)

Reverse Genetic Assessment of the Roles Played by the Spike Protein and ORF3 in Porcine Epidemic Diarrhea Virus Pathogenicity
por: Kristen-Burmann, Claudia, et al.
Publicado: (2023)

Genetic Compatibility of Reassortants between Avian H5N1 and H9N2 Influenza Viruses with Higher Pathogenicity in Mammals
por: Arai, Yasuha, et al.
Publicado: (2019)

M2 Macrophages Play Critical Roles in Progression of Inflammatory Liver Disease in Hepatitis C Virus Transgenic Mice
por: Ohtsuki, Takahiro, et al.
Publicado: (2015)

Single-Cell Landscape of Lungs Reveals Key Role of Neutrophil-Mediated Immunopathology during Lethal SARS-CoV-2 Infection
por: Zheng, Xiao-Shuang, et al.
Publicado: (2022)

A Single-Amino-Acid Substitution at Position 225 in Hemagglutinin Alters the Transmissibility of Eurasian Avian-Like H1N1 Swine Influenza Virus in Guinea Pigs
por: Wang, Zeng, et al.
Publicado: (2017)

Species-Specific Colocalization of Middle East Respiratory Syndrome Coronavirus Attachment and Entry Receptors
por: Widagdo, W., et al.
Publicado: (2019)

Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus
por: Deng, Xufang, et al.
Publicado: (2020)

Positive Selection at Key Residues in the HIV Envelope Distinguishes Broad and Strain-Specific Plasma Neutralizing Antibodies
por: Mabvakure, Batsirai M., et al.
Publicado: (2019)

TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection
por: Iwata-Yoshikawa, Naoko, et al.
Publicado: (2019)

Coronavirus Endoribonuclease and Deubiquitinating Interferon Antagonists Differentially Modulate the Host Response during Replication in Macrophages
por: Volk, Aaron, et al.
Publicado: (2020)

Skeletal Muscle Is an Early Site of Zika Virus Replication and Injury, Which Impairs Myogenesis
por: Gavino-Leopoldino, Daniel, et al.
Publicado: (2021)

Coronavirus Endoribonuclease Activity in Porcine Epidemic Diarrhea Virus Suppresses Type I and Type III Interferon Responses
por: Deng, Xufang, et al.
Publicado: (2019)

Transgene-Assisted Genetic Screen Identifies rsd-6 and Novel Genes as Key Components of Antiviral RNA Interference in Caenorhabditis elegans
por: Long, Tianyun, et al.
Publicado: (2018)

Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus
por: Iwata-Yoshikawa, Naoko, et al.
Publicado: (2019)

Comparison of Experimental Middle East Respiratory Syndrome Coronavirus Infection Acquired by Three Individual Routes of Infection in the Common Marmoset
por: Nelson, Michelle, et al.
Publicado: (2022)

Zika Virus Induces Mitotic Catastrophe in Human Neural Progenitors by Triggering Unscheduled Mitotic Entry in the Presence of DNA Damage While Functionally Depleting Nuclear PNKP
por: Rychlowska, Malgorzata, et al.
Publicado: (2022)

Quantifying and Modeling the Acquisition and Retention of Lumpy Skin Disease Virus by Hematophagus Insects Reveals Clinically but Not Subclinically Affected Cattle Are Promoters of Viral Transmission and Key Targets for Control of Disease Outbreaks
por: Sanz-Bernardo, Beatriz, et al.
Publicado: (2021)

A Novel Antigenic Site Spanning Domains I and III of the Zika Virus Envelope Glycoprotein Is the Target of Strongly Neutralizing Human Monoclonal Antibodies
por: Graham, Stephen D., et al.
Publicado: (2021)

Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site
por: Wibmer, Constantinos Kurt, et al.
Publicado: (2016)

Immune Escape Variants of H9N2 Influenza Viruses Containing Deletions at the Hemagglutinin Receptor Binding Site Retain Fitness In Vivo and Display Enhanced Zoonotic Characteristics
por: Peacock, Thomas P., et al.
Publicado: (2017)

Immunity to Seasonal Coronavirus Spike Proteins Does Not Protect from SARS-CoV-2 Challenge in a Mouse Model but Has No Detrimental Effect on Protection Mediated by COVID-19 mRNA Vaccination
por: Amanat, Fatima, et al.
Publicado: (2023)

Glycosylation of the Hemagglutinin Protein of H5N1 Influenza Virus Increases Its Virulence in Mice by Exacerbating the Host Immune Response
por: Zhao, Dongming, et al.
Publicado: (2017)

Axl Deficiency Promotes the Neuroinvasion of Japanese Encephalitis Virus by Enhancing IL-1α Production from Pyroptotic Macrophages
por: Wang, Zhao-Yang, et al.
Publicado: (2020)

Peripheral Nerve Injury Induced by Japanese Encephalitis Virus in C57BL/6 Mouse
por: Yang, Huan, et al.
Publicado: (2023)

Epitope-Containing Short Peptides Capture Distinct IgG Serodynamics That Enable Differentiating Infected from Vaccinated Animals for Live-Attenuated Vaccines
por: Xue, Qinghong, et al.
Publicado: (2020)

Naturally Occurring Single Mutations in Ebola Virus Observably Impact Infectivity
por: Wong, Gary, et al.
Publicado: (2018)

Lipopolysaccharide and Tumor Necrosis Factor Alpha Inhibit Interferon Signaling in Hepatocytes by Increasing Ubiquitin-Like Protease 18 (USP18) Expression
por: MacParland, Sonya A., et al.
Publicado: (2016)

SARS-CoV-2 Rapidly Adapts in Aged BALB/c Mice and Induces Typical Pneumonia
por: Zhang, Yufei, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_f8403cv14v5lhnb4kmvk15uhik