The PRRA Insert at the S1/S2 Site Modulates Cellular Tropism of SARS-CoV-2 and ACE2 Usage by the Closely Related Bat RaTG13

Biochemical and structural analyses suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) efficiently infects humans, and the presence of four residues (PRRA) at the S1/S2 site within the spike (S) protein may lead to unexpected tissue or host tropism. Here, we report that SARS-C...

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Detalles Bibliográficos
Autores principales: Liu, Shufeng, Selvaraj, Prabhuanand, Lien, Christopher Z., Nunez, Ivette A., Wu, Wells W., Chou, Chao-Kai, Wang, Tony T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139715/
https://www.ncbi.nlm.nih.gov/pubmed/33685917
http://dx.doi.org/10.1128/JVI.01751-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139715/
https://www.ncbi.nlm.nih.gov/pubmed/33685917
http://dx.doi.org/10.1128/JVI.01751-20

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