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The PRRA Insert at the S1/S2 Site Modulates Cellular Tropism of SARS-CoV-2 and ACE2 Usage by the Closely Related Bat RaTG13
Biochemical and structural analyses suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) efficiently infects humans, and the presence of four residues (PRRA) at the S1/S2 site within the spike (S) protein may lead to unexpected tissue or host tropism. Here, we report that SARS-C...
Autores principales: | Liu, Shufeng, Selvaraj, Prabhuanand, Lien, Christopher Z., Nunez, Ivette A., Wu, Wells W., Chou, Chao-Kai, Wang, Tony T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139715/ https://www.ncbi.nlm.nih.gov/pubmed/33685917 http://dx.doi.org/10.1128/JVI.01751-20 |
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