Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction

Neurofibrillary tangles composed of hyperphosphorylated tau and synaptic dysfunction are characteristics of Alzheimer’s disease (AD). However, the underlying molecular mechanisms remain poorly understood. Here, we identified Amphiphysin I mediates both tau phosphorylation and synaptic dysfunction in...

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Detalles Bibliográficos
Autores principales: Zhang, Xingyu, Zou, Li, Meng, Lanxia, Xiong, Min, Pan, Lina, Chen, Guiqin, Zheng, Yongfa, Xiong, Jing, Wang, Zhihao, Duong, Duc M, Zhang, Zhaohui, Cao, Xuebing, Wang, Tao, Tang, Li, Ye, Keqiang, Zhang, Zhentao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139826/
https://www.ncbi.nlm.nih.gov/pubmed/34018922
http://dx.doi.org/10.7554/eLife.65301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139826/
https://www.ncbi.nlm.nih.gov/pubmed/34018922
http://dx.doi.org/10.7554/eLife.65301

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