SAM homeostasis is regulated by CFI(m)-mediated splicing of MAT2A

S-adenosylmethionine (SAM) is the methyl donor for nearly all cellular methylation events. Cells regulate intracellular SAM levels through intron detention of MAT2A, the only SAM synthetase expressed in most cells. The N(6)-adenosine methyltransferase METTL16 promotes splicing of the MAT2A detained...

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Detalles Bibliográficos
Autores principales: Scarborough, Anna M, Flaherty, Juliana N, Hunter, Olga V, Liu, Kuanqing, Kumar, Ashwani, Xing, Chao, Tu, Benjamin P, Conrad, Nicholas K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139829/
https://www.ncbi.nlm.nih.gov/pubmed/33949310
http://dx.doi.org/10.7554/eLife.64930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139829/
https://www.ncbi.nlm.nih.gov/pubmed/33949310
http://dx.doi.org/10.7554/eLife.64930

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