Co-targeting myelin inhibitors and CSPGs markedly enhances regeneration of GDNF-stimulated, but not conditioning-lesioned, sensory axons into the spinal cord

A major barrier to intraspinal regeneration after dorsal root (DR) injury is the DR entry zone (DREZ), the CNS/PNS interface. DR axons stop regenerating at the DREZ, even if regenerative capacity is increased by a nerve conditioning lesion. This potent blockade has long been attributed to myelin-ass...

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Detalles Bibliográficos
Autores principales: Zhai, Jinbin, Kim, Hyukmin, Han, Seung Baek, Manire, Meredith, Yoo, Rachel, Pang, Shuhuan, Smith, George M, Son, Young-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139830/
https://www.ncbi.nlm.nih.gov/pubmed/33942723
http://dx.doi.org/10.7554/eLife.63050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139830/
https://www.ncbi.nlm.nih.gov/pubmed/33942723
http://dx.doi.org/10.7554/eLife.63050

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