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Co-targeting myelin inhibitors and CSPGs markedly enhances regeneration of GDNF-stimulated, but not conditioning-lesioned, sensory axons into the spinal cord
A major barrier to intraspinal regeneration after dorsal root (DR) injury is the DR entry zone (DREZ), the CNS/PNS interface. DR axons stop regenerating at the DREZ, even if regenerative capacity is increased by a nerve conditioning lesion. This potent blockade has long been attributed to myelin-ass...
Autores principales: | Zhai, Jinbin, Kim, Hyukmin, Han, Seung Baek, Manire, Meredith, Yoo, Rachel, Pang, Shuhuan, Smith, George M, Son, Young-Jin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139830/ https://www.ncbi.nlm.nih.gov/pubmed/33942723 http://dx.doi.org/10.7554/eLife.63050 |
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