A Non-APOE Polygenic Risk Score for Alzheimer’s Disease Is Associated With Cerebrospinal Fluid Neurofilament Light in a Representative Sample of Cognitively Unimpaired 70-Year Olds

The effect of Alzheimer’s disease (AD) polygenic risk scores (PRS) on amyloid and tau pathophysiology and neurodegeneration in cognitively unimpaired older adults is not known in detail. This study aims to investigate non-APOE AD-PRS and APOE ε4 in relation to AD pathophysiology evaluated by cerebro...

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Detalles Bibliográficos
Autores principales: Skoog, Ingmar, Kern, Silke, Najar, Jenna, Guerreiro, Rita, Bras, Jose, Waern, Margda, Zetterberg, Henrik, Blennow, Kaj, Zettergren, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
THE JOURNAL OF GERONTOLOGY: Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140047/
https://www.ncbi.nlm.nih.gov/pubmed/33512503
http://dx.doi.org/10.1093/gerona/glab030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140047/
https://www.ncbi.nlm.nih.gov/pubmed/33512503
http://dx.doi.org/10.1093/gerona/glab030

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