Mesenchymal stromal cell mitochondrial transfer to human induced T-regulatory cells mediates FOXP3 stability

The key obstacle to clinical application of human inducible regulatory T cells (iTreg) as an adoptive cell therapy in autoimmune disorders is loss of FOXP3 expression in an inflammatory milieu. Here we report human iTreg co-cultured with bone marrow-derived mesenchymal stromal cells (MSCs) during sh...

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Detalles Bibliográficos
Autores principales: Do, Jeong-su, Zwick, Daniel, Kenyon, Jonathan D., Zhong, Fei, Askew, David, Huang, Alex Y., Van’t Hof, Wouter, Finney, Marcie, Laughlin, Mary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140113/
https://www.ncbi.nlm.nih.gov/pubmed/34021231
http://dx.doi.org/10.1038/s41598-021-90115-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140113/
https://www.ncbi.nlm.nih.gov/pubmed/34021231
http://dx.doi.org/10.1038/s41598-021-90115-8

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