Cargando…

Mesenchymal stromal cell mitochondrial transfer to human induced T-regulatory cells mediates FOXP3 stability

The key obstacle to clinical application of human inducible regulatory T cells (iTreg) as an adoptive cell therapy in autoimmune disorders is loss of FOXP3 expression in an inflammatory milieu. Here we report human iTreg co-cultured with bone marrow-derived mesenchymal stromal cells (MSCs) during sh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Do, Jeong-su, Zwick, Daniel, Kenyon, Jonathan D., Zhong, Fei, Askew, David, Huang, Alex Y., Van’t Hof, Wouter, Finney, Marcie, Laughlin, Mary J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140113/ https://www.ncbi.nlm.nih.gov/pubmed/34021231 http://dx.doi.org/10.1038/s41598-021-90115-8

Ejemplares similares

The Synergistic Immunoregulatory Effects of Culture-Expanded Mesenchymal Stromal Cells and CD4(+)25(+)Foxp3(+) Regulatory T Cells on Skin Allograft Rejection
por: Lee, Jung Ho, et al.
Publicado: (2013)

Jagged-1 is required for the expansion of CD4(+) CD25(+) FoxP3(+) regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells
por: Cahill, Emer F, et al.
Publicado: (2015)

Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
por: Polansky, Julia K., et al.
Publicado: (2010)

Mitochondrial Transfer and Regulators of Mesenchymal Stromal Cell Function and Therapeutic Efficacy
por: Mohammadalipour, Amina, et al.
Publicado: (2020)

Human FOXP3(+) T regulatory cell heterogeneity
por: Mohr, Audrey, et al.
Publicado: (2018)

Low stromal Foxp3(+) regulatory T-cell density is associated with complete response to neoadjuvant chemoradiotherapy in rectal cancer
por: McCoy, M J, et al.
Publicado: (2015)

Therapeutic Effects of Mesenchymal Stromal Cells Require Mitochondrial Transfer and Quality Control
por: Mukkala, Avinash Naraiah, et al.
Publicado: (2023)

Mesenchymal Stromal Cell‐Seeded Biomimetic Scaffolds as a Factory of Soluble RANKL in Rankl‐Deficient Osteopetrosis
por: Menale, Ciro, et al.
Publicado: (2018)

Bone Mesenchymal Stem Cell-Derived Exosome-Enclosed miR-181a Induces CD4(+)CD25(+)FOXP3(+) Regulatory T Cells via SIRT1/Acetylation-Mediated FOXP3 Stabilization
por: Wang, Renyong, et al.
Publicado: (2022)

Effects of Natalizumab Treatment on Foxp3+ T Regulatory Cells
por: Stenner, Max-Philipp, et al.
Publicado: (2008)

Epigenetic Control of the foxp3 Locus in Regulatory T Cells
por: Floess, Stefan, et al.
Publicado: (2007)

Development of Foxp3+ regulatory T cell: epigenetics and more…
por: Hühn, Jochen
Publicado: (2011)

Functional Reprogramming of Regulatory T cells in the absence of Foxp3
por: Charbonnier, Louis-Marie, et al.
Publicado: (2019)

The Many Functions of Foxp3(+) Regulatory T Cells in the Intestine
por: Cosovanu, Catalina, et al.
Publicado: (2020)

Foxp3(+) Regulatory T Cells in Bone and Hematopoietic Homeostasis
por: Fischer, Luise, et al.
Publicado: (2019)

Milk: a postnatal imprinting system stabilizing FoxP3 expression and regulatory T cell differentiation
por: Melnik, Bodo C., et al.
Publicado: (2016)

From stability to dynamics: understanding molecular mechanisms of regulatory T cells through Foxp3 transcriptional dynamics
por: Bending, D., et al.
Publicado: (2018)

Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells
por: Fleskens, Veerle, et al.
Publicado: (2019)

Mesenteric lymph node stromal cell‐derived extracellular vesicles contribute to peripheral de novo induction of Foxp3(+) regulatory T cells
por: Pasztoi, Maria, et al.
Publicado: (2017)

Effects of mesenchymal stromal cells on regulatory T cells: Current understanding and clinical relevance
por: Negi, Neema, et al.
Publicado: (2020)

Mesenchymal stromal cell-based therapy: Regulatory and translational aspects in gastroenterology
por: Dothel, Giovanni, et al.
Publicado: (2016)

UXT is a novel regulatory factor of regulatory T cells associated with Foxp3
por: Li, Weina, et al.
Publicado: (2014)

Foxp3+ Regulatory T-cells and IL-2: The Moirai of T-cell Fates?
por: Gasteiger, Georg, et al.
Publicado: (2012)

CD4(+)Foxp3(+) regulatory T cell differentiation mediated by endometrial stromal cell-derived TECK promotes the growth and invasion of endometriotic lesions
por: Li, M-Q, et al.
Publicado: (2014)

Daurinol Attenuates Autoimmune Arthritis via Stabilization of Nrp1–PTEN–Foxp3 Signaling in Regulatory T Cells
por: Park, Min-Jung, et al.
Publicado: (2019)

PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability
por: Hurrell, Benjamin P., et al.
Publicado: (2022)

Mesenchymal Stem/Stromal Cell-Mediated Mitochondrial Transfer and the Therapeutic Potential in Treatment of Neurological Diseases
por: Han, Deqiang, et al.
Publicado: (2020)

Foxp3(+) regulatory T cells maintain immune homeostasis in the skin
por: Dudda, Jan C., et al.
Publicado: (2008)

Correction: Effects of Natalizumab Treatment on Foxp3+ T Regulatory Cells
por: Stenner, Max-Philipp, et al.
Publicado: (2010)

Foxp3(+) Regulatory T Cells Promote Lung Epithelial Proliferation
por: Mock, Jason R., et al.
Publicado: (2014)

CRISPR Screen in Regulatory T Cells Reveals Modulators of Foxp3
por: Cortez, Jessica T., et al.
Publicado: (2020)

Regulatory T Cells in Pregnancy: It Is Not All About FoxP3
por: Krop, Juliette, et al.
Publicado: (2020)

FOXP3+ regulatory T cells and the immune escape in solid tumours
por: Qiu, Yiran, et al.
Publicado: (2022)

COVID‐19 and Its Impact on Collection and Processing of Cord Blood Units at the Cleveland Cord Blood Center
por: Bobik‐Kurz, Kathy, et al.
Publicado: (2020)

Optimizing beta cell function through mesenchymal stromal cell‐mediated mitochondria transfer
por: Rackham, Chloe L., et al.
Publicado: (2020)

Identification of an immediate Foxp3(−) precursor to Foxp3(+) regulatory T cells in peripheral lymphoid organs of nonmanipulated mice
por: Schallenberg, Sonja, et al.
Publicado: (2010)

Androgen receptor modulates Foxp3 expression in CD4(+)CD25(+)Foxp3(+) regulatory T-cells
por: Walecki, Magdalena, et al.
Publicado: (2015)

Blockade of IL-27 signaling ameliorates herpes stromal keratitis with upregulated CD4(+) Foxp3(+) regulatory T cells influx in mice
por: Xia, Likun, et al.
Publicado: (2019)

Amelioration of autoimmune arthritis by adoptive transfer of Foxp3-expressing regulatory B cells is associated with the Treg/Th17 cell balance
por: Park, Mi Kyung, et al.
Publicado: (2016)

Foxp3-modified bone marrow mesenchymal stem cells promotes liver allograft tolerance through the generation of regulatory T cells in rats
por: Qi, Haizhi, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_h5j4hln3t9vu8h47id4q1ipsfu