Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia

Mitochondria are typically essential for the viability of eukaryotic cells, and utilize oxygen and nutrients (e.g. glucose) to perform key metabolic functions that maintain energetic homeostasis and support proliferation. Here we provide a comprehensive functional annotation of mitochondrial genes t...

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Detalles Bibliográficos
Autores principales: Thomas, Luke W., Esposito, Cinzia, Morgan, Rachel E., Price, Stacey, Young, Jamie, Williams, Steven P., Maddalena, Lucas A., McDermott, Ultan, Ashcroft, Margaret
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140129/
https://www.ncbi.nlm.nih.gov/pubmed/34021238
http://dx.doi.org/10.1038/s42003-021-02098-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140129/
https://www.ncbi.nlm.nih.gov/pubmed/34021238
http://dx.doi.org/10.1038/s42003-021-02098-x

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