Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes

Coronavirus disease 2019 (COVID-19) can lead to pneumonia and hyperinflammation. Here we show a sensitive method to measure polyclonal T cell activation by downstream effects on responder cells like basophils, plasmacytoid dendritic cells, monocytes and neutrophils in whole blood. We report a clear...

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Detalles Bibliográficos
Autores principales: Renner, Kerstin, Schwittay, Tobias, Chaabane, Sophia, Gottschling, Johanna, Müller, Christine, Tiefenböck, Charlotte, Salewski, Jan-Niklas, Winter, Frederike, Buchtler, Simone, Balam, Saidou, Malfertheiner, Maximilian V., Lubnow, Matthias, Lunz, Dirk, Graf, Bernhard, Hitzenbichler, Florian, Hanses, Frank, Poeck, Hendrik, Kreutz, Marina, Orsó, Evelyn, Burkhardt, Ralph, Niedermair, Tanja, Brochhausen, Christoph, Gessner, André, Salzberger, Bernd, Mack, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140132/
https://www.ncbi.nlm.nih.gov/pubmed/34021143
http://dx.doi.org/10.1038/s41467-021-23334-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140132/
https://www.ncbi.nlm.nih.gov/pubmed/34021143
http://dx.doi.org/10.1038/s41467-021-23334-2

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