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Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes
Coronavirus disease 2019 (COVID-19) can lead to pneumonia and hyperinflammation. Here we show a sensitive method to measure polyclonal T cell activation by downstream effects on responder cells like basophils, plasmacytoid dendritic cells, monocytes and neutrophils in whole blood. We report a clear...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140132/ https://www.ncbi.nlm.nih.gov/pubmed/34021143 http://dx.doi.org/10.1038/s41467-021-23334-2 |
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author | Renner, Kerstin Schwittay, Tobias Chaabane, Sophia Gottschling, Johanna Müller, Christine Tiefenböck, Charlotte Salewski, Jan-Niklas Winter, Frederike Buchtler, Simone Balam, Saidou Malfertheiner, Maximilian V. Lubnow, Matthias Lunz, Dirk Graf, Bernhard Hitzenbichler, Florian Hanses, Frank Poeck, Hendrik Kreutz, Marina Orsó, Evelyn Burkhardt, Ralph Niedermair, Tanja Brochhausen, Christoph Gessner, André Salzberger, Bernd Mack, Matthias |
author_facet | Renner, Kerstin Schwittay, Tobias Chaabane, Sophia Gottschling, Johanna Müller, Christine Tiefenböck, Charlotte Salewski, Jan-Niklas Winter, Frederike Buchtler, Simone Balam, Saidou Malfertheiner, Maximilian V. Lubnow, Matthias Lunz, Dirk Graf, Bernhard Hitzenbichler, Florian Hanses, Frank Poeck, Hendrik Kreutz, Marina Orsó, Evelyn Burkhardt, Ralph Niedermair, Tanja Brochhausen, Christoph Gessner, André Salzberger, Bernd Mack, Matthias |
author_sort | Renner, Kerstin |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19) can lead to pneumonia and hyperinflammation. Here we show a sensitive method to measure polyclonal T cell activation by downstream effects on responder cells like basophils, plasmacytoid dendritic cells, monocytes and neutrophils in whole blood. We report a clear T cell hyporeactivity in hospitalized COVID-19 patients that is pronounced in ventilated patients, associated with prolonged virus persistence and reversible with clinical recovery. COVID-19-induced T cell hyporeactivity is T cell extrinsic and caused by plasma components, independent of occasional immunosuppressive medication of the patients. Monocytes respond stronger in males than females and IL-2 partially restores T cell activation. Downstream markers of T cell hyporeactivity are also visible in fresh blood samples of ventilated patients. Based on our data we developed a score to predict fatal outcomes and identify patients that may benefit from strategies to overcome T cell hyporeactivity. |
format | Online Article Text |
id | pubmed-8140132 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-81401322021-06-07 Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes Renner, Kerstin Schwittay, Tobias Chaabane, Sophia Gottschling, Johanna Müller, Christine Tiefenböck, Charlotte Salewski, Jan-Niklas Winter, Frederike Buchtler, Simone Balam, Saidou Malfertheiner, Maximilian V. Lubnow, Matthias Lunz, Dirk Graf, Bernhard Hitzenbichler, Florian Hanses, Frank Poeck, Hendrik Kreutz, Marina Orsó, Evelyn Burkhardt, Ralph Niedermair, Tanja Brochhausen, Christoph Gessner, André Salzberger, Bernd Mack, Matthias Nat Commun Article Coronavirus disease 2019 (COVID-19) can lead to pneumonia and hyperinflammation. Here we show a sensitive method to measure polyclonal T cell activation by downstream effects on responder cells like basophils, plasmacytoid dendritic cells, monocytes and neutrophils in whole blood. We report a clear T cell hyporeactivity in hospitalized COVID-19 patients that is pronounced in ventilated patients, associated with prolonged virus persistence and reversible with clinical recovery. COVID-19-induced T cell hyporeactivity is T cell extrinsic and caused by plasma components, independent of occasional immunosuppressive medication of the patients. Monocytes respond stronger in males than females and IL-2 partially restores T cell activation. Downstream markers of T cell hyporeactivity are also visible in fresh blood samples of ventilated patients. Based on our data we developed a score to predict fatal outcomes and identify patients that may benefit from strategies to overcome T cell hyporeactivity. Nature Publishing Group UK 2021-05-21 /pmc/articles/PMC8140132/ /pubmed/34021143 http://dx.doi.org/10.1038/s41467-021-23334-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Renner, Kerstin Schwittay, Tobias Chaabane, Sophia Gottschling, Johanna Müller, Christine Tiefenböck, Charlotte Salewski, Jan-Niklas Winter, Frederike Buchtler, Simone Balam, Saidou Malfertheiner, Maximilian V. Lubnow, Matthias Lunz, Dirk Graf, Bernhard Hitzenbichler, Florian Hanses, Frank Poeck, Hendrik Kreutz, Marina Orsó, Evelyn Burkhardt, Ralph Niedermair, Tanja Brochhausen, Christoph Gessner, André Salzberger, Bernd Mack, Matthias Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes |
title | Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes |
title_full | Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes |
title_fullStr | Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes |
title_full_unstemmed | Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes |
title_short | Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes |
title_sort | severe t cell hyporeactivity in ventilated covid-19 patients correlates with prolonged virus persistence and poor outcomes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140132/ https://www.ncbi.nlm.nih.gov/pubmed/34021143 http://dx.doi.org/10.1038/s41467-021-23334-2 |
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