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Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes
Coronavirus disease 2019 (COVID-19) can lead to pneumonia and hyperinflammation. Here we show a sensitive method to measure polyclonal T cell activation by downstream effects on responder cells like basophils, plasmacytoid dendritic cells, monocytes and neutrophils in whole blood. We report a clear...
Autores principales: | Renner, Kerstin, Schwittay, Tobias, Chaabane, Sophia, Gottschling, Johanna, Müller, Christine, Tiefenböck, Charlotte, Salewski, Jan-Niklas, Winter, Frederike, Buchtler, Simone, Balam, Saidou, Malfertheiner, Maximilian V., Lubnow, Matthias, Lunz, Dirk, Graf, Bernhard, Hitzenbichler, Florian, Hanses, Frank, Poeck, Hendrik, Kreutz, Marina, Orsó, Evelyn, Burkhardt, Ralph, Niedermair, Tanja, Brochhausen, Christoph, Gessner, André, Salzberger, Bernd, Mack, Matthias |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140132/ https://www.ncbi.nlm.nih.gov/pubmed/34021143 http://dx.doi.org/10.1038/s41467-021-23334-2 |
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