SPOP–PTEN–SUFU axis promotes progression of clear cell renal cell carcinoma via activating SHH and WNT pathway

Although E3 ligase Speckle type BTB/POZ protein (SPOP) promotes tumorigenesis by acting as a key regulatory hub in clear cell renal cell carcinoma (ccRCC), the detailed molecular mechanism remains unclear. Here, we demonstrate that a well-known tumor suppressor, Suppressor of Fused (SUFU), is downre...

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Detalles Bibliográficos
Autores principales: Han, Bo’ang, Sun, Zhen, Yu, Tingting, Wang, Yu, Kuang, Lun, Li, Tianyuan, Cai, Jing, Cao, Qing, Xu, Yuan, Gao, Binbin, Cheng, Steven Y., Yue, Shen, Liu, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140158/
https://www.ncbi.nlm.nih.gov/pubmed/34021128
http://dx.doi.org/10.1038/s41420-021-00484-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140158/
https://www.ncbi.nlm.nih.gov/pubmed/34021128
http://dx.doi.org/10.1038/s41420-021-00484-2

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