Including random centre effects in design, analysis and presentation of multi-centre trials

BACKGROUND: In large multicentre trials in diverse settings, there is uncertainty about the need to adjust for centre variation in design and analysis. A key distinction is the difference between variation in outcome (independent of treatment) and variation in treatment effect. Through re-analysis o...

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Detalles Bibliográficos
Autores principales: Edgar, Kate, Roberts, Ian, Sharples, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140487/
https://www.ncbi.nlm.nih.gov/pubmed/34022937
http://dx.doi.org/10.1186/s13063-021-05266-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140487/
https://www.ncbi.nlm.nih.gov/pubmed/34022937
http://dx.doi.org/10.1186/s13063-021-05266-w

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