TCONS_00230836 silencing restores stearic acid-induced β cell dysfunction through alleviating endoplasmic reticulum stress rather than apoptosis

BACKGROUND: Chronic exposure of pancreatic β cells to high levels of stearic acid (C18:0) leads to impaired insulin secretion, which accelerates the progression of type 2 diabetes mellitus (T2DM). Recently, long noncoding RNAs (lncRNAs) were found to participate in saturated fatty acid-induced metab...

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Detalles Bibliográficos
Autores principales: Guo, Rui, Zhang, Yunjin, Yu, Yue, Su, Shenghan, Zhao, Qingrui, Chu, Xia, Li, Shenglong, Lu✉, Huimin, Sun, Changhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140511/
https://www.ncbi.nlm.nih.gov/pubmed/34022799
http://dx.doi.org/10.1186/s12263-021-00685-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140511/
https://www.ncbi.nlm.nih.gov/pubmed/34022799
http://dx.doi.org/10.1186/s12263-021-00685-5

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