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TCONS_00230836 silencing restores stearic acid-induced β cell dysfunction through alleviating endoplasmic reticulum stress rather than apoptosis

BACKGROUND: Chronic exposure of pancreatic β cells to high levels of stearic acid (C18:0) leads to impaired insulin secretion, which accelerates the progression of type 2 diabetes mellitus (T2DM). Recently, long noncoding RNAs (lncRNAs) were found to participate in saturated fatty acid-induced metab...

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Detalles Bibliográficos
Autores principales:	Guo, Rui, Zhang, Yunjin, Yu, Yue, Su, Shenghan, Zhao, Qingrui, Chu, Xia, Li, Shenglong, Lu✉, Huimin, Sun, Changhao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140511/ https://www.ncbi.nlm.nih.gov/pubmed/34022799 http://dx.doi.org/10.1186/s12263-021-00685-5

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