Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma

BACKGROUND: Amplification of the MYCN oncogene is a molecular hallmark of aggressive neuroblastoma (NB), a childhood cancer of the sympathetic nervous system. There is evidence that MYCN promotes a non-inflamed and T-cell infiltration-poor (‘cold’) tumor microenvironment (TME) by suppressing interfe...

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Detalles Bibliográficos
Autores principales: Seier, Johanna A, Reinhardt, Julia, Saraf, Kritika, Ng, Susanna S, Layer, Julian P, Corvino, Dillon, Althoff, Kristina, Giordano, Frank A, Schramm, Alexander, Fischer, Matthias, Hölzel, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141444/
https://www.ncbi.nlm.nih.gov/pubmed/34016720
http://dx.doi.org/10.1136/jitc-2020-001335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141444/
https://www.ncbi.nlm.nih.gov/pubmed/34016720
http://dx.doi.org/10.1136/jitc-2020-001335

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