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Physical Stability and Dissolution of Lumefantrine Amorphous Solid Dispersions Produced by Spray Anti-Solvent Precipitation

This study aims to develop amorphous solid dispersion (ASD) of lumefantrine with a cost-effective approach of spray anti-solvent precipitation. Four acidic polymers, hydroxypropylmethylcellulose phthalate (HPMCP), hydroxypropylmethylcellulose acetate succinate (HPMCAS), poly(methacrylic acid–ethyl a...

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Detalles Bibliográficos
Autores principales: Bhujbal, Sonal V., Pathak, Vaibhav, Zemlyanov, Dmitry Y., Taylor, Lynne S., Zhou, Qi (Tony)
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141512/
https://www.ncbi.nlm.nih.gov/pubmed/33387599
http://dx.doi.org/10.1016/j.xphs.2020.12.033