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Design of novel peptide inhibitors against the conserved bacterial transcription terminator, Rho

The transcription terminator Rho regulates many physiological processes in bacteria, such as antibiotic sensitivity, DNA repair, RNA remodeling, and so forth, and hence, is a potential antimicrobial target, which is unexplored. The bacteriophage P4 capsid protein, Psu, moonlights as a natural Rho an...

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Detalles Bibliográficos
Autores principales: Ghosh, Gairika, Sharma, Pankaj V., Kumar, Amit, Jain, Sriyans, Sen, Ranjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141534/
https://www.ncbi.nlm.nih.gov/pubmed/33845047
http://dx.doi.org/10.1016/j.jbc.2021.100653