lncRNA TRMP-S directs dual mechanisms to regulate p27-mediated cellular senescence

Long noncoding RNAs (lncRNAs) undergo extensive alternative splicing, but little is known about isoform functions. A prior investigation of lncRNA RP11-369C8.1 reported that its splice variant TRMP suppressed p27 translation through PTBP1. Here we characterize a second major splice variant, TRMP-S (...

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Detalles Bibliográficos
Autores principales: Shuai, Tian, Khan, Muhammad Riaz, Zhang, Xu Dong, Li, Jingmin, Thorne, Rick Francis, Wu, Mian, Shao, Fengmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141606/
https://www.ncbi.nlm.nih.gov/pubmed/34094715
http://dx.doi.org/10.1016/j.omtn.2021.04.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141606/
https://www.ncbi.nlm.nih.gov/pubmed/34094715
http://dx.doi.org/10.1016/j.omtn.2021.04.004

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