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lncRNA TRMP-S directs dual mechanisms to regulate p27-mediated cellular senescence
Long noncoding RNAs (lncRNAs) undergo extensive alternative splicing, but little is known about isoform functions. A prior investigation of lncRNA RP11-369C8.1 reported that its splice variant TRMP suppressed p27 translation through PTBP1. Here we characterize a second major splice variant, TRMP-S (...
Autores principales: | Shuai, Tian, Khan, Muhammad Riaz, Zhang, Xu Dong, Li, Jingmin, Thorne, Rick Francis, Wu, Mian, Shao, Fengmin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141606/ https://www.ncbi.nlm.nih.gov/pubmed/34094715 http://dx.doi.org/10.1016/j.omtn.2021.04.004 |
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