Design of a Trispecific Checkpoint Inhibitor and Natural Killer Cell Engager Based on a 2 + 1 Common Light Chain Antibody Architecture

Natural killer cell engagers gained enormous interest in recent years due to their potent anti-tumor activity and favorable safety profile. Simultaneously, chicken-derived antibodies entered clinical studies paving the way for avian-derived therapeutics. In this study, we describe the affinity matur...

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Detalles Bibliográficos
Autores principales: Bogen, Jan P., Carrara, Stefania C., Fiebig, David, Grzeschik, Julius, Hock, Björn, Kolmar, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141644/
https://www.ncbi.nlm.nih.gov/pubmed/34040611
http://dx.doi.org/10.3389/fimmu.2021.669496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141644/
https://www.ncbi.nlm.nih.gov/pubmed/34040611
http://dx.doi.org/10.3389/fimmu.2021.669496

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