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Structural diversity of the coenzyme methylofuran and identification of enzymes for the biosynthesis of its polyglutamate side chain

Methylofuran (MYFR) is a formyl-carrying coenzyme essential for the oxidation of formaldehyde in most methylotrophic bacteria. In Methylorubrum extorquens, MYFR contains a large and branched polyglutamate side chain of up to 24 glutamates. These glutamates play an essential role in interfacing the c...

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Detalles Bibliográficos
Autores principales: Hemmann, Jethro L., Brühwiler, Manuel R., Bortfeld-Miller, Miriam, Vorholt, Julia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141765/
https://www.ncbi.nlm.nih.gov/pubmed/33894199
http://dx.doi.org/10.1016/j.jbc.2021.100682