Polyphyllin Ⅲ-Induced Ferroptosis in MDA-MB-231 Triple-Negative Breast Cancer Cells can Be Protected Against by KLF4-Mediated Upregulation of xCT

Ferroptosis, which is characterized by the accumulation of intracellular iron and subsequent lipid peroxidation, is a newly discovered form of regulated cell death and plays an important role in tumor suppression. Herein, we showed that Polyphyllin III, which is a major saponin extracted from Paris...

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Detalles Bibliográficos
Autores principales: Zhou, Yulu, Yang, Jingjing, Chen, Cong, Li, Zhaoqing, Chen, Yongxia, Zhang, Xun, Wang, Linbo, Zhou, Jichun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141818/
https://www.ncbi.nlm.nih.gov/pubmed/34040532
http://dx.doi.org/10.3389/fphar.2021.670224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141818/
https://www.ncbi.nlm.nih.gov/pubmed/34040532
http://dx.doi.org/10.3389/fphar.2021.670224

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