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Polyphyllin Ⅲ-Induced Ferroptosis in MDA-MB-231 Triple-Negative Breast Cancer Cells can Be Protected Against by KLF4-Mediated Upregulation of xCT
Ferroptosis, which is characterized by the accumulation of intracellular iron and subsequent lipid peroxidation, is a newly discovered form of regulated cell death and plays an important role in tumor suppression. Herein, we showed that Polyphyllin III, which is a major saponin extracted from Paris...
Autores principales: | Zhou, Yulu, Yang, Jingjing, Chen, Cong, Li, Zhaoqing, Chen, Yongxia, Zhang, Xun, Wang, Linbo, Zhou, Jichun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141818/ https://www.ncbi.nlm.nih.gov/pubmed/34040532 http://dx.doi.org/10.3389/fphar.2021.670224 |
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