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The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate

N-acetylneuraminate (Neu5Ac), an abundant sugar present in glycans in vertebrates and some bacteria, can be used as an energy source by several prokaryotes, including Escherichia coli. In solution, more than 99% of Neu5Ac is in cyclic form (≈92% beta-anomer and ≈7% alpha-anomer), whereas <0.5% is...

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Detalles Bibliográficos
Autores principales: Kentache, Takfarinas, Thabault, Leopold, Deumer, Gladys, Haufroid, Vincent, Frédérick, Raphaël, Linster, Carole L., Peracchi, Alessio, Veiga-da-Cunha, Maria, Bommer, Guido T., Van Schaftingen, Emile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141875/
https://www.ncbi.nlm.nih.gov/pubmed/33895133
http://dx.doi.org/10.1016/j.jbc.2021.100699