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The α3 subunit of GABA(A) receptors promotes formation of inhibitory synapses in the absence of collybistin

Signaling at nerve cell synapses is a key determinant of proper brain function, and synaptic defects—or synaptopathies—are at the basis of many neurological and psychiatric disorders. Collybistin (CB), a brain-specific guanine nucleotide exchange factor, is essential for the formation of γ-aminobuty...

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Detalles Bibliográficos
Autores principales: Wagner, Sven, Lee, ChoongKu, Rojas, Lucia, Specht, Christian G., Rhee, JeongSeop, Brose, Nils, Papadopoulos, Theofilos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141935/
https://www.ncbi.nlm.nih.gov/pubmed/33901490
http://dx.doi.org/10.1016/j.jbc.2021.100709