Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo

BACKGROUND: Mutations in LRRK2 are the most common cause of familial Parkinson’s disease and typically cause disease in the context of abnormal aggregation and deposition of α-synuclein within affected brain tissue. METHODS: We combine genetic analysis of Lrrk-associated toxicity in a penetrant Dros...

Descripción completa

Detalles Bibliográficos
Autores principales: Sarkar, Souvarish, Bardai, Farah, Olsen, Abby L., Lohr, Kelly M., Zhang, Ying-Yi, Feany, Mel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142648/
https://www.ncbi.nlm.nih.gov/pubmed/34030727
http://dx.doi.org/10.1186/s13024-021-00454-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142648/
https://www.ncbi.nlm.nih.gov/pubmed/34030727
http://dx.doi.org/10.1186/s13024-021-00454-3

Ejemplares similares