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Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo
BACKGROUND: Mutations in LRRK2 are the most common cause of familial Parkinson’s disease and typically cause disease in the context of abnormal aggregation and deposition of α-synuclein within affected brain tissue. METHODS: We combine genetic analysis of Lrrk-associated toxicity in a penetrant Dros...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142648/ https://www.ncbi.nlm.nih.gov/pubmed/34030727 http://dx.doi.org/10.1186/s13024-021-00454-3 |