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Inhibition of Retinal Ganglion Cell Loss By a Novel ROCK Inhibitor (E212) in Ischemic Optic Nerve Injury Via Antioxidative and Anti-Inflammatory Actions

PURPOSE: This study investigated the neuroprotective effects of administration of ROCK inhibitor E212 on ischemic optic neuropathy. METHODS: Rats received an intravitreal injection of either E212 or PBS immediately after optic nerve infarct. The oxidative stress in the retina was detected by perform...

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Detalles Bibliográficos
Autores principales: Wen, Yao-Tseng, Huang, Ching-Wen, Liu, Chih-Peng, Chen, Chih-Hung, Tu, Chia-Mu, Hwang, Chrong-Shiong, Chen, Yi-Hsun, Chen, Wan-Ru, Lin, Keh-Liang, Ho, Yu-Chieh, Chen, Ta-Ching, Tsai, Rong-Kung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142697/
https://www.ncbi.nlm.nih.gov/pubmed/34015079
http://dx.doi.org/10.1167/iovs.62.6.21