Targeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication

Treatment options for COVID-19 remain limited, especially during the early or asymptomatic phase. Here, we report a novel SARS-CoV-2 viral replication mechanism mediated by interactions between ACE2 and the epigenetic eraser enzyme LSD1, and its interplay with the nuclear shuttling importin pathway....

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Detalles Bibliográficos
Autores principales: Tu, Wen Juan, McCuaig, Robert D., Melino, Michelle, Rawle, Daniel J., Le, Thuy T., Yan, Kexin, Suhrbier, Andreas, Johnston, Rebecca L., Koufariotis, Lambros T., Waddell, Nicola, Cross, Emily M., Tsimbalyuk, Sofiya, Bain, Amanda, Ahern, Elizabeth, Collinson, Natasha, Phipps, Simon, Forwood, Jade K., Seddiki, Nabila, Rao, Sudha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143069/
https://www.ncbi.nlm.nih.gov/pubmed/34031383
http://dx.doi.org/10.1038/s41421-021-00279-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143069/
https://www.ncbi.nlm.nih.gov/pubmed/34031383
http://dx.doi.org/10.1038/s41421-021-00279-w

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