PK/PD Modeling of the PDE7 Inhibitor—GRMS-55 in a Mouse Model of Autoimmune Hepatitis

This study aimed to assess the efficacy and explore the mechanisms of action of a potent phosphodiesterase (PDE)7A and a moderate PDE4B inhibitor GRMS-55 in a mouse model of autoimmune hepatitis (AIH). The concentrations of GRMS-55 and relevant biomarkers were measured in the serum of BALB/c mice wi...

Descripción completa

Detalles Bibliográficos
Autores principales: Świerczek, Artur, Plutecka, Hanna, Ślusarczyk, Marietta, Chłoń-Rzepa, Grażyna, Wyska, Elżbieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143339/
https://www.ncbi.nlm.nih.gov/pubmed/33919375
http://dx.doi.org/10.3390/pharmaceutics13050597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143339/
https://www.ncbi.nlm.nih.gov/pubmed/33919375
http://dx.doi.org/10.3390/pharmaceutics13050597

Ejemplares similares