Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin

Accidental exposure to ionizing radiation may lead to delayed effects of acute radiation exposure (DEARE) in many organ systems. Activated protein C (APC) is a known mitigator of the acute radiation syndrome. To examine the role of APC in DEARE, we used a transgenic mouse model with 2- to 3-fold inc...

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Detalles Bibliográficos
Autores principales: Sridharan, Vijayalakshmi, Johnson, Kristin A., Landes, Reid D., Cao, Maohua, Singh, Preeti, Wagoner, Gail, Hayar, Abdallah, Sprick, Emily D., Eveld, Kayla A., Bhattacharyya, Anusha, Krager, Kimberly J., Aykin-Burns, Nukhet, Weiler, Hartmut, Fernández, Jose A., Griffin, John H., Boerma, Marjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143413/
https://www.ncbi.nlm.nih.gov/pubmed/34029348
http://dx.doi.org/10.1371/journal.pone.0252142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143413/
https://www.ncbi.nlm.nih.gov/pubmed/34029348
http://dx.doi.org/10.1371/journal.pone.0252142

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