A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin(2α)-induced corpus luteum regression

Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) normally signals to necroptosis by phosphorylating MLKL. We report here that when the cellular RIPK3 chaperone Hsp90/CDC37 level is low, RIPK3 also signals to apoptosis. The apoptotic function of RIPK3 requires phosphorylation of the ser...

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Detalles Bibliográficos
Autores principales: Li, Dianrong, Chen, Jie, Guo, Jia, Li, Lin, Cai, Gaihong, Chen, She, Huang, Jia, Yang, Hui, Zhuang, Yinhua, Wang, Fengchao, Wang, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143796/
https://www.ncbi.nlm.nih.gov/pubmed/34029184
http://dx.doi.org/10.7554/eLife.67409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143796/
https://www.ncbi.nlm.nih.gov/pubmed/34029184
http://dx.doi.org/10.7554/eLife.67409

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