Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate

SARM1 regulates axonal degeneration through its NAD-metabolizing activity and is a drug target for neurodegenerative disorders. We designed and synthesized fluorescent conjugates of styryl derivative with pyridine to serve as substrates of SARM1, which exhibited large red shifts after conversion. Wi...

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Detalles Bibliográficos
Autores principales: Li, Wan Hua, Huang, Ke, Cai, Yang, Wang, Qian Wen, Zhu, Wen Jie, Hou, Yun Nan, Wang, Sujing, Cao, Sheng, Zhao, Zhi Ying, Xie, Xu Jie, Du, Yang, Lee, Chi-Sing, Lee, Hon Cheung, Zhang, Hongmin, Zhao, Yong Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143800/
https://www.ncbi.nlm.nih.gov/pubmed/33944777
http://dx.doi.org/10.7554/eLife.67381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143800/
https://www.ncbi.nlm.nih.gov/pubmed/33944777
http://dx.doi.org/10.7554/eLife.67381

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