Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells

Manufacturing of recombinant adeno-associated virus (rAAV) viral vectors remains challenging, with low yields and low full:empty capsid ratios in the harvest. To elucidate the dynamics of recombinant viral production, we develop a mechanistic model for the synthesis of rAAV viral vectors by triple p...

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Detalles Bibliográficos
Autores principales: Nguyen, Tam N.T., Sha, Sha, Hong, Moo Sun, Maloney, Andrew J., Barone, Paul W., Neufeld, Caleb, Wolfrum, Jacqueline, Springs, Stacy L., Sinskey, Anthony J., Braatz, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143981/
https://www.ncbi.nlm.nih.gov/pubmed/34095346
http://dx.doi.org/10.1016/j.omtm.2021.04.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143981/
https://www.ncbi.nlm.nih.gov/pubmed/34095346
http://dx.doi.org/10.1016/j.omtm.2021.04.006

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