Olaparib increases the therapeutic index of hemithoracic irradiation compared with hemithoracic irradiation alone in a mouse lung cancer model

BACKGROUND: The radiosensitising effect of the poly(ADP-ribose) polymerase inhibitor olaparib on tumours has been reported. However, its effect on normal tissues in combination with radiation has not been well studied. Herein, we investigated the therapeutic index of olaparib combined with hemithora...

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Detalles Bibliográficos
Autores principales: Jiang, Yanyan, Martin, Jennifer, Alkadhimi, Maryam, Shigemori, Kay, Kinchesh, Paul, Gilchrist, Stuart, Kersemans, Veerle, Smart, Sean, Thompson, James M., Hill, Mark A., O’Connor, Mark J., Davies, Barry R., Ryan, Anderson J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144220/
https://www.ncbi.nlm.nih.gov/pubmed/33742147
http://dx.doi.org/10.1038/s41416-021-01296-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144220/
https://www.ncbi.nlm.nih.gov/pubmed/33742147
http://dx.doi.org/10.1038/s41416-021-01296-y

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