Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase

All herpesviruses encode a conserved DNA polymerase that is required for viral genome replication and serves as an important therapeutic target. Currently available herpesvirus therapies include nucleoside and non-nucleoside inhibitors (NNI) that target the DNA-bound state of herpesvirus polymerase...

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Detalles Bibliográficos
Autores principales: Hayes, Robert P., Heo, Mee Ra, Mason, Mark, Reid, John, Burlein, Christine, Armacost, Kira A., Tellers, David M., Raheem, Izzat, Shaw, Anthony W., Murray, Edward, McKenna, Philip M., Abeywickrema, Pravien, Sharma, Sujata, Soisson, Stephen M., Klein, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144222/
https://www.ncbi.nlm.nih.gov/pubmed/34031403
http://dx.doi.org/10.1038/s41467-021-23312-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144222/
https://www.ncbi.nlm.nih.gov/pubmed/34031403
http://dx.doi.org/10.1038/s41467-021-23312-8

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