Block of TREK and TRESK K2P channels by lamotrigine and two derivatives sipatrigine and CEN-092

TREK and TRESK K2P channels are widely expressed in the nervous system, particularly in sensory neurons, where they regulate neuronal excitability. In this study, using whole-cell patch-clamp electrophysiology, we characterise the inhibitory effect of the anticonvulsant lamotrigine and two derivativ...

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Detalles Bibliográficos
Autores principales: Walsh, Yvonne, Leach, Michael, Veale, Emma L., Mathie, Alistair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144350/
https://www.ncbi.nlm.nih.gov/pubmed/34041373
http://dx.doi.org/10.1016/j.bbrep.2021.101021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144350/
https://www.ncbi.nlm.nih.gov/pubmed/34041373
http://dx.doi.org/10.1016/j.bbrep.2021.101021

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