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Block of TREK and TRESK K2P channels by lamotrigine and two derivatives sipatrigine and CEN-092
TREK and TRESK K2P channels are widely expressed in the nervous system, particularly in sensory neurons, where they regulate neuronal excitability. In this study, using whole-cell patch-clamp electrophysiology, we characterise the inhibitory effect of the anticonvulsant lamotrigine and two derivativ...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144350/ https://www.ncbi.nlm.nih.gov/pubmed/34041373 http://dx.doi.org/10.1016/j.bbrep.2021.101021 |