A novel synthetic microtubule inhibitor exerts antiproliferative effects in multidrug resistant cancer cells and cancer stem cells

The success of cancer chemotherapy is limited by multidrug resistance (MDR), which is mainly caused by P-glycoprotein (P-gp) overexpression. In the present study, we describe a novel microtubule inhibitor, 5-(N-methylmaleimid-3-yl)-chromone (SPC-160002), that can be used to overcome MDR. A synthetic...

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Detalles Bibliográficos
Autores principales: Park, Mina, Hwang, Jee Won, Cho, Yena, Kim, Saegun, Han, Sang Hoon, Yu, Jinsuh, Ha, Sojung, Kim, Woo-Young, Kim, Su-Nam, Kim, In Su, Kim, Yong Kee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144389/
https://www.ncbi.nlm.nih.gov/pubmed/34031528
http://dx.doi.org/10.1038/s41598-021-90337-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144389/
https://www.ncbi.nlm.nih.gov/pubmed/34031528
http://dx.doi.org/10.1038/s41598-021-90337-w

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