Haploinsufficiency of the schizophrenia and autism risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms

Genetic risk factors can significantly increase chances of developing psychiatric disorders, but the underlying biological processes through which this risk is effected remain largely unknown. Here we show that haploinsufficiency of Cyfip1, a candidate risk gene present in the pathogenic 15q11.2(BP1...

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Detalles Bibliográficos
Autores principales: Haan, Niels, Westacott, Laura J., Carter, Jenny, Owen, Michael J., Gray, William P., Hall, Jeremy, Wilkinson, Lawrence S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144403/
https://www.ncbi.nlm.nih.gov/pubmed/34031371
http://dx.doi.org/10.1038/s41398-021-01415-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144403/
https://www.ncbi.nlm.nih.gov/pubmed/34031371
http://dx.doi.org/10.1038/s41398-021-01415-6

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