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Mining mutation contexts across the cancer genome to map tumor site of origin

The vast preponderance of somatic mutations in a typical cancer are either extremely rare or have never been previously recorded in available databases that track somatic mutations. These constitute a hidden genome that contrasts the relatively small number of mutations that occur frequently, the pr...

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Detalles Bibliográficos
Autores principales: Chakraborty, Saptarshi, Martin, Axel, Guan, Zoe, Begg, Colin B., Shen, Ronglai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144407/
https://www.ncbi.nlm.nih.gov/pubmed/34031376
http://dx.doi.org/10.1038/s41467-021-23094-z